Differin Gel isn't like other over-the-counter (OTC) acne treatments you've tried. It contains the first new FDA-approved OTC active ingredient to fight acne in more than 30 years. Differin works differently than other acne treatments by normalizing skin cell turnover and effectively targets two primary causes of acne, clogged pores and inflammation. Always use a gentle cleanser and moisturizer when using Differin Gel. Use of a moisturizer may help decrease dryness and other signs of irritation. Differin Gel is proven to be safe and effective and contains 0.1% adapalene, an acne-fighting retinoid dermatologists have prescribed to over 40 million people globally for more than 20 years. The American Academy of Dermatology recommends topical retinoids as a first-line therapy for all acne cases.